Department of Medical Information, Chongqing Medical University, Chongqing 400016, China.
Eur J Surg Oncol. 2010 Dec;36(12):1149-55. doi: 10.1016/j.ejso.2010.09.012.
Minimally-invasive thermal ablation techniques provide an effective approach for local destruction of solid tumor. A novel application is the use for treatment of early-stage breast carcinoma.
A broad search was conducted in Pubmed, Embase and the Cochrane databases between January 1990 and December 2009. Clinical results of the relevant articles were collected and analyzed.
The analyzed studies were almost all feasibility or pilot studies using different energy sources, patients, tumor characteristics and ablation settings. They were conducted in research settings for the assessment of technical safety and feasibility, and none of those was used alone in clinical practice. Despite many methodological differences, complete tumor ablation could be achieved in 76-100% of breast cancer patients treated with radiofrequency ablation, 13-76% in laser ablation, 0-8% in microwave ablation, 36-83% in cryoablation, and 20-100% in high-intensity focused ultrasound ablation.
Minimally-invasive thermal ablation is a promising new tool for local destruction of small carcinomas of the breast. Large randomized control studies are required to assess the long-term advantages of minimally-invasive thermal ablation techniques compared to the current breast conserving therapies.
微创热消融技术为实体肿瘤的局部破坏提供了一种有效方法。一种新的应用是用于治疗早期乳腺癌。
在 1990 年 1 月至 2009 年 12 月期间，在 Pubmed、Embase 和 Cochrane 数据库中进行了广泛的搜索。收集并分析了相关文章的临床结果。
分析的研究几乎都是使用不同能量源、患者、肿瘤特征和消融设置的可行性或初步研究。这些研究都是在研究环境中进行的，用于评估技术的安全性和可行性，而且没有一项单独用于临床实践。尽管存在许多方法学上的差异，但使用射频消融治疗的乳腺癌患者中，完全肿瘤消融的比例为 76-100%，激光消融为 13-76%，微波消融为 0-8%，冷冻消融为 36-83%，高强度聚焦超声消融为 20-100%。
微创热消融是一种有前途的用于局部破坏小乳腺癌的新工具。需要进行大型随机对照研究，以评估微创热消融技术与目前的保乳治疗相比的长期优势。
