Department of Health Risk Analysis and Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, The Netherlands.
J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):38-44. doi: 10.1093/gerona/glq164. Epub 2010 Oct 1.
Telomere shortening is a marker of aging and therefore telomere length might be related to disease progression and survival. To address these questions, we measured leukocyte telomere length (LTL) in male participants from the Zutphen Elderly Study. LTL was measured by quantitative polymerase chain reaction in 203 men: mean aged 78 years in 1993 and 75 surviving participants mean aged 83 years in 2000. During 7 years of follow-up, 105 men died. Cox proportional hazards models were used to estimate hazard ratios for all-cause and cause-specific mortality. We found that LTL declined with a mean of 40.2 bp/year, and LTL values measured in 1993 and 2000 correlated significantly (r = .51, p < .001). Longer telomeres at baseline were not predictive for all-cause mortality, cardiovascular mortality, or cancer mortality. These results suggest that LTL decreases with increasing age and that LTL is not related to mortality in men aged more than 70 years.
端粒缩短是衰老的标志，因此端粒长度可能与疾病进展和生存有关。为了解决这些问题，我们测量了祖特芬老年研究中男性参与者的白细胞端粒长度 (LTL)。LTL 通过定量聚合酶链反应在 203 名男性中进行测量：1993 年平均年龄为 78 岁，2000 年有 75 名幸存参与者，平均年龄为 83 岁。在 7 年的随访期间，有 105 名男性死亡。使用 Cox 比例风险模型估计全因和特定原因死亡率的风险比。我们发现 LTL 每年平均下降 40.2 bp，1993 年和 2000 年测量的 LTL 值显著相关（r =.51，p <.001）。基线时较长的端粒并不能预测全因死亡率、心血管死亡率或癌症死亡率。这些结果表明，LTL 随年龄增长而降低，并且 LTL 与 70 岁以上男性的死亡率无关。
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