链霉菌 clavuligerus NRRL 3585 的基因组草图，该菌是多种次级代谢产物的生产者。
Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.
机构信息
Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
出版信息
J Bacteriol. 2010 Dec;192(23):6317-8. doi: 10.1128/JB.00859-10. Epub 2010 Oct 1.
Abstract
Streptomyces clavuligerus is an important industrial strain that produces a number of antibiotics, including clavulanic acid and cephamycin C. A high-quality draft genome sequence of the S. clavuligerus NRRL 3585 strain was produced by employing a hybrid approach that involved Sanger sequencing, Roche/454 pyrosequencing, optical mapping, and partial finishing. Its genome, comprising four linear replicons, one chromosome, and four plasmids, carries numerous sets of genes involved in the biosynthesis of secondary metabolites, including a variety of antibiotics.
摘要
产克拉维酸链霉菌是一种重要的工业菌株，能够产生多种抗生素，包括克拉维酸和头孢菌素 C。通过采用混合测序方法，包括 Sanger 测序、罗氏/454 焦磷酸测序、光学图谱和部分测序，获得了产克拉维酸链霉菌 NRRL 3585 菌株的高质量基因组草图序列。该菌株的基因组由四个线性复制子、一个染色体和四个质粒组成，携带有大量参与次生代谢物生物合成的基因簇，包括各种抗生素。
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