Department of Internal Medicine, University of California Irvine School of Medicine, Irvine, CA, USA.
J Immigr Minor Health. 2011 Oct;13(5):842-8. doi: 10.1007/s10903-010-9395-8.
The incidence of HCC is rising worldwide. Studies on ethnicity-based clinical presentation of HCC remain limited. The aim is to compare the clinical presentation and stage of HCC between Asian-Americans and non-Asian-Americans. This retrospective study assessed ethnicity-based differences in HCC presentation, including demographics, laboratory results, diagnosis of underlying liver disease, and stage of HCC. Of 276 patients, 162 were Asian-Americans and 114 were non-Asian-Americans. Compared to non-Asian-Americans, Asian-Americans had a significantly higher incidence of history of hepatitis B virus (HBV) infection (55.0% vs. 4.9%, P < 0.001), family history of HBV infection (12.5% vs. 0.0%, P < 0.001) and HCC (15.2% vs. 2.9%, P = 0.002), but lower incidence of history of hepatitis C virus (HCV) infection (37.5% vs. 61.6%, P < 0.001). At diagnosis of HCC, Asian-American patients had a significantly lower frequency of hepatic encephalopathy (8.9% vs. 29.3%, P = 0.001), and ascites (26.7% vs. 57.3%, P < 0.001). Asian-Americans had lower Child-Pugh scores (class A: 62.0% vs. 31.4%, P < 0.001), and MELD scores (9.2 ± 4.4 vs. 12.0 ± 6.4, P = 0.02), and presented with a lower stage of HCC by Okuda staging (I: 43.8% vs. 22.8%, P = 0.001). Asian-American patients with HCC presented with a higher incidence of history and family history of HBV infection, lower incidence of hepatic decompensation, lower Child and MELD scores, and an early stage HCC disease.
HCC 的发病率在全球范围内呈上升趋势。基于种族的 HCC 临床表现研究仍然有限。本研究旨在比较亚裔美国人和非亚裔美国人 HCC 的临床表现和分期。本回顾性研究评估了基于种族的 HCC 表现差异，包括人口统计学、实验室结果、潜在肝病的诊断以及 HCC 的分期。在 276 名患者中，162 名是亚裔美国人，114 名是非亚裔美国人。与非亚裔美国人相比，亚裔美国人乙型肝炎病毒 (HBV) 感染史（55.0%比 4.9%，P<0.001）、HBV 家族史（12.5%比 0.0%，P<0.001）和 HCC 家族史（15.2%比 2.9%，P=0.002）的发生率明显更高，但丙型肝炎病毒 (HCV) 感染史（37.5%比 61.6%，P<0.001）的发生率较低。在 HCC 诊断时，亚裔美国人肝性脑病（8.9%比 29.3%，P=0.001）和腹水（26.7%比 57.3%，P<0.001）的频率明显较低。亚裔美国人的 Child-Pugh 评分（A级：62.0%比 31.4%，P<0.001）和 MELD 评分（9.2±4.4 比 12.0±6.4，P=0.02）较低，Okuda 分期 HCC 分期较低（I 期：43.8%比 22.8%，P=0.001）。患有 HCC 的亚裔美国人 HBV 感染史和家族史发生率较高，肝失代偿发生率较低，Child 和 MELD 评分较低，早期 HCC 疾病。
