Sheridan Brian S, Lefrançois Leo
Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
Curr Gastroenterol Rep. 2010 Dec;12(6):513-21. doi: 10.1007/s11894-010-0148-6.
The mucosal immune system is constantly exposed to a wide range of commensal and potentially pathogenic microbial species. Chronic exposure to foreign organisms makes generation of an appropriate immune response critical in maintaining a balance between elimination of harmful pathogens, peaceful coexistence with commensals, and prevention of autoimmunity. Intestinal intraepithelial lymphocytes provide a first line of defense at this extensive barrier with the outside world, and as such, understanding their role in immunity is critical.
黏膜免疫系统持续暴露于种类繁多的共生微生物和潜在致病微生物。长期接触外来生物体使得产生适当的免疫反应对于维持消除有害病原体、与共生菌和平共处以及预防自身免疫之间的平衡至关重要。肠道上皮内淋巴细胞在这个与外界的广泛屏障处提供了第一道防线，因此，了解它们在免疫中的作用至关重要。
