Beniwal Poonam, Harrell Laura
Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Curr Gastroenterol Rep. 2010 Dec;12(6):479-84. doi: 10.1007/s11894-010-0145-9.
Inflammatory bowel disease (IBD), which includes ulcerative colitis, Crohn's disease, and indeterminate colitis, is characterized by chronic inflammation of the digestive tract and has a significant impact on quality of life. Coupled with clinical history, physicians rely on invasive tests (e.g. endoscopy and radiologic examinations) to diagnose IBD. Patients with other gastrointestinal illnesses (e.g. irritable bowel syndrome and celiac disease) may present with symptoms similar to those of an IBD patient. Therefore, a need exists for rapid and noninvasive measures to indicate the presence of IBD. The identification of potential biomarkers associated with IBD has expanded rapidly in the past decade. This article reviews the role of recently studied serologic and fecal markers in the diagnosis of IBD, and differentiation between subtypes of IBD.
炎症性肠病（IBD）包括溃疡性结肠炎、克罗恩病和未定型结肠炎，其特征为消化道的慢性炎症，对生活质量有重大影响。结合临床病史，医生依靠侵入性检查（如内窥镜检查和放射学检查）来诊断IBD。患有其他胃肠道疾病（如肠易激综合征和乳糜泻）的患者可能会出现与IBD患者相似的症状。因此，需要快速且非侵入性的措施来指示IBD的存在。在过去十年中，与IBD相关的潜在生物标志物的识别迅速增加。本文综述了最近研究的血清学和粪便标志物在IBD诊断以及IBD亚型鉴别中的作用。
