粪便钙卫蛋白在炎症性肠病研究中的作用。
The role of fecal calprotectin in investigating inflammatory bowel diseases.
机构信息
Gastroenterology Department, Fatih University Hospital, Ankara, Turkey.
出版信息
Clinics (Sao Paulo). 2009 May;64(5):421-5. doi: 10.1590/s1807-59322009000500009.
Abstract
INTRODUCTION
Invasive and non-invasive tests can be used to evaluate the activity of inflammatory bowel diseases.
OBJECTIVE
The aim of the present study was to investigate the role of fecal calprotectin in evaluating inflammatory bowel disease activity and the correlation of fecal calprotectin with the erythrocyte sedimentation rate and C reactive protein values in inflammatory bowel disease.
METHOD
Sixty-five patients affected with inflammatory bowel disease were enrolled. Twenty outpatients diagnosed with inflammatory bowel disease comprised the control group.
RESULTS
In the present study, all patients in the control group had an fecal calprotectin value lower than the cut-off point (50 mg/kg).
CONCLUSION
In conclusion, fecal calprotectin was found to be strongly associated with colorectal inflammation indicating organic disease. Fecal calprotectin is a simple and non-invasive method for assessing excretion of macrophages into the gut lumen. Fecal calprotectin values can be used to evaluate the response to treatment, to screen asymptomatic patients, and to predict inflammatory bowel disease relapses.
摘要
简介
可采用侵入性和非侵入性检查来评估炎症性肠病的活动度。
目的
本研究旨在探讨粪便钙卫蛋白在评估炎症性肠病活动度中的作用，以及粪便钙卫蛋白与炎症性肠病患者红细胞沉降率和 C 反应蛋白值的相关性。
方法
纳入 65 例炎症性肠病患者，20 例门诊诊断为炎症性肠病的患者作为对照组。
结果
在本研究中，对照组所有患者的粪便钙卫蛋白值均低于临界值（50mg/kg）。
结论
总之，粪便钙卫蛋白与结直肠炎症密切相关，提示存在器质性疾病。粪便钙卫蛋白是一种简单、非侵入性的方法，用于评估巨噬细胞向肠道腔道的排泄。粪便钙卫蛋白值可用于评估治疗反应、筛查无症状患者以及预测炎症性肠病复发。
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