Gara Sonia, Abessi Meriem, Bendjemena Katia, Abdennebi Monia, Guemira Fethi
Department of Clinical Biology, Cancer Institute Salah Azaiez, Tunis.
Tunis Med. 2010 Oct;88(10):700-2.
Glutathione S-transferases (GST) play a vital role in cellular defense against environmentally toxic compounds. These enzymes present a genetic deletion polymorphism, which varies with ethnicity.
To evaluate the frequencies of homozygous deletion of GSTM1 and GSTT1 genes in Tunisian population.
On the basis of multiplex PCR protocol, the frequency of the deleted genotypes of GSTM1 and GSTT1 genes was evaluated on 145 healthy Tunisian subjects.
We found that 34.6% of the individuals had the GSTM1 null genotype, 16.6% had the GSTT1 null genotype and 4.82% had a double deletion of both GSTM1 and GSTT1.
The distribution of GSTM1 null in Tunisians is rather in the range of black populations and is lower than that reported in Asians, Arabs and Caucasians. However the frequency of GSTT1 null is in the range of several populations studied except Asians. The double deletion frequency seems lower than that described in different populations.
谷胱甘肽S-转移酶（GST）在细胞抵御环境有毒化合物中发挥着至关重要的作用。这些酶存在基因缺失多态性，且因种族不同而有所差异。
评估突尼斯人群中GSTM1和GSTT1基因纯合缺失的频率。
基于多重PCR方案，对145名健康突尼斯受试者评估GSTM1和GSTT1基因缺失基因型的频率。
我们发现34.6%的个体具有GSTM1无效基因型，16.6%具有GSTT1无效基因型，4.82%同时存在GSTM1和GSTT1的双重缺失。
突尼斯人中GSTM1无效基因型的分布情况与黑人人群相当，低于亚洲人、阿拉伯人和高加索人中所报道的分布情况。然而，GSTT1无效基因型的频率除亚洲人外，与其他多个研究人群的范围相当。双重缺失频率似乎低于不同人群中所描述的频率。
