Ro 19-6327对兔组织和人血小板中MAO-B的抑制作用呈现相似的时间进程。

MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time-course.

作者信息

Kettler R, Cesura A M, Dingemanse J, Da Prada M

机构信息

Pharmaceutical Department F. Hoffmann-La Roche Ltd. Basel, Switzerland.

出版信息

J Neural Transm Suppl. 1990;32:211-4. doi: 10.1007/978-3-7091-9113-2_31.

DOI:10.1007/978-3-7091-9113-2_31

PMID:2089093

Abstract

In rabbits, 3 mg/kg Ro 19-6327 p.o., induced complete monoamine oxidase type B (MAO-B) inhibition in striatum, cerebral cortex, liver and platelets for about 12 h. In healthy human volunteers complete inhibition of platelet MAO was obtained with only 5 mg Ro 19-6327. After 40 and 200 mg Ro 19-6327 the duration of complete MAO-B inhibition was prolonged to 12 and 24 hours, respectively. Changes in brain MAO-B in humans after Ro 19-6327 are likely to be faithfully reflected by platelet MAO activity.

摘要

在兔子中，口服3mg/kg的Ro 19-6327可使纹状体、大脑皮层、肝脏和血小板中的单胺氧化酶B型（MAO-B）完全抑制约12小时。在健康人类志愿者中，仅5mg的Ro 19-6327就能使血小板MAO完全抑制。服用40mg和200mg的Ro 19-6327后，MAO-B完全抑制的持续时间分别延长至12小时和24小时。Ro 19-6327作用于人类后，大脑中MAO-B的变化可能会通过血小板MAO活性得到如实反映。