Horn H, Morgenstern E, Unverferth K
Sektion Biowissenschaften der Universität Leipzig.
Pharmazie. 1990 Oct;45(10):724-7.
The title compounds, starting from variously substituted beta-benzoylpropionic or beta-benzoylbenzoic acids, were prepared by cyclocondensation with alpha-ethylhydrazinoacetate monohydrochloride and subsequent alcaline hydrolysis or aminolysis of the 2-carbethoxymethyl-1,2,5,6-tetrahydro-1-oxo-pyridazines or 1,2-dihydro-1-oxo-phthalazines respectively. The 1-oxo-phthalazines 42 and 34 have a weak anticonvulsive effect. Like a large number of the other synthezized compounds, they show a central sedative component and are relatively nontoxic.
从各种取代的β-苯甲酰基丙酸或β-苯甲酰基苯甲酸出发，通过与α-乙基肼基乙酸酯盐酸盐进行环缩合，然后分别对2-乙氧羰基甲基-1,2,5,6-四氢-1-氧代哒嗪或1,2-二氢-1-氧代酞嗪进行碱性水解或氨解，制备了标题化合物。1-氧代酞嗪42和34具有微弱的抗惊厥作用。与大量其他合成化合物一样，它们具有中枢镇静成分且相对无毒。
