Linhartová A
Sikl's Pathologisch-Anatomisches Institut, Medizinischen Fakultät, Karls-Universität Plzen, CSFR.
Zentralbl Allg Pathol. 1990;136(7-8):679-87.
Electron microscopy is an important supplementary tool in bioptic diagnosis of bone marrow lesions. The hematologically specialised clinical pathologist should better resort to it for all bone marrow investigations. The routine pathologist can focus attention at least on certain diagnostic cases, such as children, or on sequential biopsies with specific diagnostic problems. It will be necessary, in such cases, to use proper fixation and, before further processing to cut the bone marrow sample into small pieces without delay. Electron microscopy has worked well, in the context of our own material, for differential diagnosis between various forms of myelogenous leukemia, hypereosinophilia of bone marrow and lymphocytic leukemia as well as between immature multiple myeloma and malignant lymphoma, centrocytic/centroblastic malignant lymphoma and nodular sclerosis of Hodgkin's disease and in the diagnosis of megakaryocytic leukemia.
电子显微镜检查是骨髓病变活检诊断中的一项重要辅助工具。血液学专业的临床病理学家在所有骨髓检查中都应更好地借助它。常规病理学家至少可以将注意力集中在某些诊断病例上，比如儿童病例，或者有特定诊断问题的连续活检病例。在这种情况下，有必要进行适当固定，并在进一步处理之前立即将骨髓样本切成小块。就我们自己的材料而言，电子显微镜检查在各种形式的骨髓性白血病、骨髓嗜酸性粒细胞增多症和淋巴细胞白血病之间的鉴别诊断，以及未成熟多发性骨髓瘤与恶性淋巴瘤、中心细胞/中心母细胞性恶性淋巴瘤与霍奇金病结节硬化之间的鉴别诊断，以及在巨核细胞白血病的诊断中都发挥了很好的作用。
