Jorge L, Pereira M E, de Matos H, Patrício M B
Departamento de Radioterapia, Instituto Português de Oncologia de Francisco Gentil, Lisboa.
Acta Med Port. 1990 Nov-Dec;3(6):337-40.
Preliminary results of hiperfraccionated total body irradiation (TBI) in eleven patients with acute leukemia (mean age 11.4 years) as conditioning for allogeneic bone marrow transplantation are presented. The linear accelerator was always used for photon irradiation in 3 daily fractions of 120 cGy, to a total dose of 1320 cGy in 4 days. With a follow-up of 3-24 months we obtained good results. The average time for durable engraftment was 22 days and only 2 patients died; one early after the engraftment and another with hepatic veno-occlusive disease 4 months later. There were no cases of intersticial pneumonitis. Due to the good results, although the number of the patients was small, and the follow-up short, the authors propose to continue this protocol until November 1990.
本文介绍了对11例急性白血病患者（平均年龄11.4岁）进行超分割全身照射（TBI）作为异基因骨髓移植预处理的初步结果。直线加速器始终用于光子照射，每日3次，每次120 cGy，4天内总剂量达1320 cGy。经过3至24个月的随访，我们取得了良好的结果。持久植入的平均时间为22天，仅2例患者死亡；1例在植入后不久死亡，另1例在4个月后死于肝静脉闭塞性疾病。无间质性肺炎病例。鉴于结果良好，尽管患者数量较少且随访时间较短，作者建议将该方案持续至1990年11月。
