Arbit E, Rubinstein A, DiResta G, Lee J, Ali F, Galicich J H
Memorial Sloan-Kettering Cancer Center, New York, New York.
Acta Neurochir Suppl (Wien). 1990;51:158-9. doi: 10.1007/978-3-7091-9115-6_53.
U-78517G belongs to a novel group of compounds-aminosteroids (AS) which are potent inhibitors of central nervous system tissue lipid peroxidation and are devoid of classical glucocorticoid and mineralocorticoid activities. The AS have been found to possess cerebral protective properties against ischaemia, ischaemic oedema, trauma to the cerebrum and spinal cord and in sub-arachnoid hemorrhage. The possible efficacy of U-78517G in attenuating peritumoural oedema was examined in rats harbouring cerebral 9L gliosarcomas. 19 Sprague-Dawley rats were implanted intracranially with 9L gliosarcoma cells. On day 14 post implantation rats were randomized to control (no treatment n = 10) and AS treated animals (n = 9). On day 20 animals were sacrificed and six brain samples per rat were examined for the percentage of water content. Oedema was assessed with the wet/dry weight technique. The AS treated animals were found to have a significant increase in peritumoural oedema (+1.38%, P less than 0.001) possibly related to an increase in cerebral blood flow associated with AS treatment. Further studies are, however, underway to precisely clarify this unexpected observation.
U-78517G属于一类新型化合物——氨基甾体（AS），它是中枢神经系统组织脂质过氧化的强效抑制剂，且不具有典型的糖皮质激素和盐皮质激素活性。已发现AS具有针对缺血、缺血性水肿、大脑和脊髓创伤以及蛛网膜下腔出血的脑保护特性。在患有脑9L胶质肉瘤的大鼠中检测了U-78517G减轻肿瘤周围水肿的可能疗效。将19只Sprague-Dawley大鼠颅内植入9L胶质肉瘤细胞。植入后第14天，将大鼠随机分为对照组（未治疗，n = 10）和AS治疗组（n = 9）。在第20天处死动物，检查每只大鼠的六个脑样本的含水量百分比。采用湿/干重技术评估水肿。发现接受AS治疗的动物肿瘤周围水肿显著增加（+1.38%，P小于0.001），这可能与AS治疗相关的脑血流量增加有关。然而，正在进行进一步研究以准确阐明这一意外观察结果。
