van den Brink W A, Marmarou A, Avezaat C J
Medical College of Virginia, Richmond.
Acta Neurochir Suppl (Wien). 1990;51:261-2. doi: 10.1007/978-3-7091-9115-6_88.
Development of brain oedema was studied in a new closed head injury (CHI) model of the rat. This acceleration impact models does not produce the dramatic blood pressure surge seen with fluid percussion injury. Sixteen Sprague Dawley rats were separated into 4 groups; 8 survivors sacrified at 4 and 24 hours post injury; and 8 Sham treated animals sacrified at the same time intervals. Brains were analyzed using gravimetric technique. Despite absence of the high post traumatic blood pressure surge, mild oedema was observed in 4 of 5 slices at 4 hours post injury. At 24 hours post injury, significant oedema was observed throughout the brain tissue. The study demonstrates that traumatic oedema develops following acceleration impact within a 24 hour period of CHI. The oedema occurs in the absence of significant brain stem damage and blood pressure rise characteristic of this new CHI model.
在一种新的大鼠闭合性颅脑损伤（CHI）模型中研究了脑水肿的发展情况。这种加速撞击模型不会产生液体冲击伤时出现的剧烈血压波动。将16只Sprague Dawley大鼠分为4组；8只存活大鼠在受伤后4小时和24小时处死；8只假手术处理的动物在相同时间间隔处死。使用重量法分析大脑。尽管没有创伤后高血压的剧烈波动，但在受伤后4小时，5个脑片中的4个出现了轻度水肿。在受伤后24小时，整个脑组织均观察到明显水肿。该研究表明，在CHI的24小时内，加速撞击后会发生创伤性水肿。在这种新的CHI模型中，水肿是在没有明显脑干损伤和血压升高的情况下发生的。
