Makabe O, Miyadera A, Kinoshita M, Umezawa S
J Antibiot (Tokyo). 1978 May;31(5):456-67. doi: 10.7164/antibiotics.31.456.
The syntheses of N1- and N2-isopropylformycin (10, 11), formycin 3',5'-cyclic and 2',3'-cyclic phosphate (3,7) and their N-methyl and N-isopropyl derivatives (13, 15, 19, 23) are described. It was observed that substitution at N1 or N2 with a bulky alkyl group or cyclic phosphorylation of the ribose moiety made formycin resistant to adenosine deaminase.
描述了N1-和N2-异丙基间型霉素（10, 11）、间型霉素3',5'-环磷酸酯和2',3'-环磷酸酯（3,7）及其N-甲基和N-异丙基衍生物（13, 15, 19, 23）的合成。据观察，在N1或N2处用庞大的烷基取代或核糖部分的环磷酸化使间型霉素对腺苷脱氨酶具有抗性。
