[全身溶解状态作为心肌梗死静脉推注rt-PA后治疗成功的标志物]
[Systemic lytic state as marker of therapeutic success after rt-PA in bolus in myocardial infarction].
作者信息
Tranchesi Júnior B, Caramelli B, Gebara O C, Santos Filho R D, de Albuquerque C P, Matsumoto C, Bellotti G, Chamone D, Pileggi F
机构信息
Instituto do Coração do Hospital das Clínicas, FMUSP.
出版信息
Arq Bras Cardiol. 1990 Nov;55(5):291-3.
PURPOSE
Evaluate the lytic state (LS) expressed by the level of plasmatic fibrinogen (PF) after rt-PA "in bolus" infusion for acute myocardial infarction (MI) and its relation to coronary reperfusion.
PATIENTS AND METHODS
Fifty-one patients (38 men, mean age of 53.0 +/- 9.8 years) with demonstrated occlusion of the infarct related artery (IRA) received an intravenous bolus infusion of 70 mg of rt-PA, PF was assessed before and 90 minutes after the treatment and the levels were compared in patients with (group 1) and without (group 2) reperfusion of the IRA.
RESULTS
Basal levels of PF were within the normal range in all patients. There was a decrement of 35.1% in the PF dosed at 90 minutes, from 276.8 +/- 55.5 mg/dl to 168.0 +/- 68.2 mg/dl. Both groups were similar in the levels of PF 90 after treatment (145.1 +/- 95.7 mg/dl in group 1 versus 187.0 +/- 53.7 mg/dl in group 2).
CONCLUSION
"In bolus" rt-PA treatment for MI significantly reduces the PF, but the LS obtained was similar in patients with or without reperfusion of the IRA.
目的
评估急性心肌梗死（MI）患者静脉推注重组组织型纤溶酶原激活剂（rt-PA）后血浆纤维蛋白原（PF）水平所表达的溶解状态（LS）及其与冠状动脉再灌注的关系。
患者与方法
51例（38例男性，平均年龄53.0±9.8岁）梗死相关动脉（IRA）闭塞的患者接受了70mg rt-PA静脉推注，在治疗前和治疗后90分钟评估PF，并对IRA再灌注患者（第1组）和未再灌注患者（第2组）的水平进行比较。
结果
所有患者的PF基础水平均在正常范围内。90分钟时PF剂量下降了35.1%，从276.8±55.5mg/dl降至168.0±68.2mg/dl。两组治疗后90分钟的PF水平相似（第1组为145.1±95.7mg/dl，第2组为187.0±53.7mg/dl）。
结论
MI患者静脉推注rt-PA治疗可显著降低PF，但IRA再灌注患者和未再灌注患者获得的LS相似。
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