针鼹（短吻针鼹）和鸭嘴兽（鸭嘴兽）的铁（III）结合蛋白

Iron(III) binding proteins of echidna (Tachyglossus aculeatus) and platypus (Ornithorhynchus anatinus).

作者信息

Teahan C G, McKenzie H A

机构信息

Protein Chemistry Group, John Curtin School of Medical Research, Australian National University, Canberra.

出版信息

Biochem Int. 1990 Oct;22(2):321-8.

PMID:2090097

Abstract

Iron (III) binding proteins are isolated from echidna (Tachyglossus aculeatus multiaculeatus) and platypus (Ornithorhynchus anatinus) milk and blood. On the basis of several criteria it is shown that the milk proteins are not lactoferrins, but are transferrins similar to the corresponding transferrins from the blood. The heterogeneity of the proteins, particularly the echidna milk transferrin, is, at least in part, due to different levels of sialic acid. Their N-terminal sequences (30 residues) are determined and compared with those of other transferrins and lactoferrins. The role of the proteins is discussed.

摘要

从针鼹（多刺针鼹）和鸭嘴兽的乳汁及血液中分离出铁（III）结合蛋白。基于多项标准表明，乳汁中的蛋白质并非乳铁蛋白，而是与血液中相应转铁蛋白相似的转铁蛋白。这些蛋白质的异质性，尤其是针鼹乳汁转铁蛋白的异质性，至少部分是由于唾液酸水平不同所致。测定了它们的N端序列（30个残基），并与其他转铁蛋白和乳铁蛋白的序列进行了比较。还讨论了这些蛋白质的作用。