Synthesis of a new class of 1,4-dihydropyridines having a hydroxamic ester group in position 3 with a potential calcium antagonistic activity.

The synthesis of new 1,4-dihydropyridines having a hydroxamic acid or hydroxamic ester group in position 3 is described. Pharmacological evaluation included calcium antagonistic activity in the guinea pig Taenia coli test and acute toxicity. The compounds had not a calcium antagonistic activity, if compared with other well known DHP utilized as standard, so the pharmacological tests were not furtherly studied.