Zeidler J M, Zimmermann W, Roth H J
Pharmazeutisches Institut, Universität Tübingen, F.R.G.
Chem Phys Lipids. 1990 Aug;55(2):155-61. doi: 10.1016/0009-3084(90)90076-4.
The synthesis of azathia analogues of the platelet activating factor with oxygen and sulphur-containing sidechains is reported. The starting point is 1-acetylthio-3-hydroxy-2-propaneamine-HCl, which permits the formation of the thioether and the acetamido linkage in one step. The phosphocholine part is introduced via 2-chloro-2-oxo-1,3,2-dioxaphospholane and subsequent ring opening with trimethylamine under pressure.
