Seto Y, Ikeuchi Y, Kanehisa M
Protein Research Foundation, Peptide Institute, Osaka, Japan.
Proteins. 1990;8(4):341-51. doi: 10.1002/prot.340080408.
From protein sequence comparison data found in the literature, a library was organized using peptide fragment sequences which are common to related proteins. Each of the fragments was then examined for its occurrence in all the protein superfamilies defined by the NBRF-PIR data base. We have selected those fragment peptides that appear exclusively in one or a few superfamilies, and thus made a library of fragment peptides that characterize specific superfamilies. Such characteristic peptides are, in general, five to seven residues long and contain unusually high proportions of glycine and cysteine. This collection is a useful resource for the classification and functional prediction of protein molecules.
根据文献中蛋白质序列比较数据，利用相关蛋白质共有的肽片段序列构建了一个文库。然后检查每个片段在由NBRF-PIR数据库定义的所有蛋白质超家族中的出现情况。我们选择了那些仅出现在一个或几个超家族中的片段肽，从而构建了一个表征特定超家族的片段肽文库。这些特征肽一般长度为五到七个残基，且甘氨酸和半胱氨酸的比例异常高。这个集合是蛋白质分子分类和功能预测的有用资源。
