Labiós M, Romero M, Gabriel F, Fuster E, Tatay E, Vallés R
Unidad Hipertensión, Hospital Clínico Universitario, Facultad de Medicina de Valencia.
Rev Clin Esp. 1990 Sep;187(4):158-61.
We have studied a group of 33 (27 female and 6 male) patients suffering pure essential arterial hypertension, with a mean age of 54.06 years, and who received a daily monodose of chlortalidone. Arterial pressure, blood viscosity at different shearing levels, as well as those parameters capable of modifying this viscosity were determined at days 0, 30, 60, 90, and 180 of treatment. Similarly, blood viscosity in this group of patients on day 0 is compared to a normotense control group. We observed a statistically significant (p less than 0.05) increase in blood viscosity in the hypertense group at day 0 when compared to the control group. No significant changes due to treatment could be observed in blood viscosity or any of the parameters studied. However, there was a significant decrease (p less than 0.0001) in arterial blood viscosity. "Chronic" treatment of essential hypertense patients have an inherent increase in blood viscosity. "Chronic" treatment of essential arterial hypertension with diuretics (chlortalidone) does not modify the hematocrit nor other biochemical parameters studies, nor blood viscosity. Treatment normalises blood pressure levels, but it does not "primarily" hemodynamically prevent ischemic events at the microcirculatory level.
我们研究了一组33名（27名女性和6名男性）单纯原发性动脉高血压患者，他们的平均年龄为54.06岁，每天接受单剂量氯噻酮治疗。在治疗的第0、30、60、90和180天测定动脉血压、不同剪切水平下的血液粘度以及能够改变这种粘度的参数。同样，将这组患者第0天的血液粘度与血压正常的对照组进行比较。我们观察到，与对照组相比，高血压组在第0天血液粘度有统计学意义的升高（p<0.05）。在血液粘度或所研究的任何参数中，未观察到因治疗导致的显著变化。然而，动脉血粘度有显著降低（p<0.0001）。原发性高血压患者的“长期”治疗会使血液粘度固有增加。用利尿剂（氯噻酮）对原发性动脉高血压进行“长期”治疗不会改变血细胞比容或其他所研究的生化参数，也不会改变血液粘度。治疗可使血压水平正常化，但它并不能在微循环水平“主要”从血液动力学方面预防缺血事件。
