Pérez Arellano J L, Rodríguez Rodríguez E, Romero Furones A, Moreno de Vega y Lomo V, Sánchez Sánchez R, León Moya V, González Villarón L
Servicio de Medicina Interna II, Hospital Clínico Universitario, Salamanca.
Rev Clin Esp. 1990 Oct;187(6):284-6.
Familial sarcoidosis is a pathologic association rarely described in the Spanish literature. We present a study of a family in which two members were clinically affected (Löfgren's syndrome) existing subclinical pathological signs in the rest. Based on this association the epidemiological, clinical and pathogenic mechanisms of familial sarcoidosis are reviewed with special attention to the incidence of this association in literature (in the Spanish literature in particular) and in the study of histocompatibility antigens in these patients. To conclude, the importance of investigating in a directed manner, the existence of familial sarcoidosis is emphasized since it offers an exceptional opportunity for the study of the pathogenic aspects (genetic and environmental) of this disease.
家族性结节病是一种在西班牙文献中很少被描述的病理关联。我们报告了一个家族的研究，该家族中有两名成员出现临床症状（ Löfgren综合征），其余成员存在亚临床病理体征。基于这种关联，我们回顾了家族性结节病的流行病学、临床和致病机制，特别关注该关联在文献（尤其是西班牙文献）中的发生率以及这些患者的组织相容性抗原研究。最后，强调了有针对性地调查家族性结节病存在的重要性，因为它为研究该疾病的致病方面（遗传和环境）提供了一个特殊的机会。
