Yasujima M, Abe K, Tanno M, Kohzuki M, Kanazawa M, Yoshida K, Omata K, Sato M, Takeuchi K, Hiwatari M
Institute of Rehabilitation Medicine, University School of Medicine, Sendai, Japan.
Tohoku J Exp Med. 1990 Nov;162(3):203-12. doi: 10.1620/tjem.162.203.
To investigate the interaction of cardiac glycosides with vasoconstrictors, we examined the effects of short term treatment with the cardiac glycoside digoxin (6 mg/kg/day, i.p., for 6 days) in rats made hypertensive by chronic infusion of norepinephrine (NE), angiotensin II (A II) or vasopressin (VP). When digoxin was administered simultaneously with NE at 1.8 mg/kg/day (i.p.) by use of osmotic minipumps in conscious rats, systolic blood pressure decreased to 120 +/- 3 mmHg on Day 1 whereas it rose to 148 +/- 2 mmHg in rats given NE alone (p less than 0.01). The antihypertensive effect of digoxin was sustained for the entire experimental period and was not associated with any change in urinary sodium excretion. When the same dose of digoxin was administered simultaneously with A II at 900 micrograms/kg/day (i.p.) in conscious rats, systolic blood pressure rose to a greater extent than in those given A II alone. The administration of digoxin had no effect on the blood pressure elevation induced by chronic infusion of VP at a rate of 7.2 U/kg/day (i.p.). It is concluded that short term treatment with digoxin has a variety of effects on blood pressure in rats; pressor, depressor, or is no effects depending upon vasoconstrictor used.
为研究强心苷与血管收缩剂的相互作用，我们检测了地高辛短期治疗（6毫克/千克/天，腹腔注射，共6天）对通过慢性输注去甲肾上腺素（NE）、血管紧张素II（A II）或血管加压素（VP）诱导高血压大鼠的影响。当在清醒大鼠中通过渗透微型泵以1.8毫克/千克/天（腹腔注射）同时给予地高辛和NE时，收缩压在第1天降至120±3毫米汞柱，而单独给予NE的大鼠收缩压升至148±2毫米汞柱（p<0.01）。地高辛的降压作用在整个实验期间持续存在，且与尿钠排泄的任何变化无关。当在清醒大鼠中以900微克/千克/天（腹腔注射）同时给予相同剂量的地高辛和A II时，收缩压升高幅度大于单独给予A II的大鼠。给予地高辛对以7.2单位/千克/天（腹腔注射）慢性输注VP诱导的血压升高没有影响。结论是，地高辛短期治疗对大鼠血压有多种影响；升压、降压或无影响，这取决于所使用的血管收缩剂。
