Ertuğ H, Arman M, Yeğin O
Department of Pediatrics, Akdeniz University Faculty of Medicine, Antalya.
Turk J Pediatr. 1990 Apr-Jun;32(2):73-8.
Neutrophil, monocyte and lymphocyte chemotaxis was investigated in 19 patients with active rheumatic fever (10 with carditis), in 15 patients with rheumatoid arthritis and in 20 healthy, age-matched controls. Chemotaxis assays were repeated in the rheumatic fever patients on the fifth day of therapy and two weeks after remission. Neutrophil and monocyte chemotaxis was found to be significantly decreased in the rheumatoid arthritis patients when compared with the controls and rheumatic fever patients. In contrast, neutrophil chemotactic activity was significantly higher in the rheumatic fever patients when compared with the healthy controls. Monocyte and lymphocyte chemotaxis in patients with rheumatic fever was not significantly different when compared with the controls. Neutrophil, monocyte and lymphocyte locomotion was found to be significantly decreased on the fifth day of salicylic acid or prednisolone treatment.
对19例活动性风湿热患者（其中10例有心脏炎）、15例类风湿关节炎患者以及20名年龄匹配的健康对照者进行了中性粒细胞、单核细胞和淋巴细胞趋化性研究。对风湿热患者在治疗第5天和缓解后两周重复进行趋化性检测。结果发现，与对照组和风湿热患者相比，类风湿关节炎患者的中性粒细胞和单核细胞趋化性显著降低。相比之下，与健康对照组相比，风湿热患者的中性粒细胞趋化活性显著更高。与对照组相比，风湿热患者的单核细胞和淋巴细胞趋化性无显著差异。在水杨酸或泼尼松龙治疗的第5天，发现中性粒细胞、单核细胞和淋巴细胞的移动性显著降低。
