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[接受传统免疫抑制治疗的肾移植患者及接受环孢素A治疗的肾移植患者术后的动脉高血压]

[Arterial hypertension following kidney transplantation in patients on conventional immunosuppressive therapy and in those treated with cyclosporin A].

作者信息

Beleva B

出版信息

Vutr Boles. 1990;29(6):47-51.

PMID:2091383
Abstract

The frequency and the causes of arterial hypertension following renal transplantation were studied in 109 patients (110 renal transplantations). 75 patients with efficient renal function were followed up for one year. 46 + 2 of these patients received Azathioprin and 27 of them had arterial hypertension. Cycloeporin A received 29 + 2 patients and 18 of them had arterial hypertension. In the patients treated with Azathioprin a significantly greater frequency and higher values of the arterial pressure were found than in the patients treated with Cycloprorin A. A weak reverse relation was established between the arterial pressure and the serum cyclosporin A level. The arterial pressure was highest during the first month, slightly decreased at the third month and then rose again, later. Basic causes of arterial hypertension were the rejection reactions, the patients' own kidneys which were left in their place, arterial stenosis of the transplant.

摘要

对109例患者(110次肾移植)肾移植后动脉高血压的发生率及病因进行了研究。对75例肾功能良好的患者进行了为期一年的随访。其中46 + 2例患者接受硫唑嘌呤治疗,27例患有动脉高血压。29 + 2例患者接受环孢素A治疗,其中18例患有动脉高血压。在接受硫唑嘌呤治疗的患者中,发现动脉压的发生率和值明显高于接受环孢素A治疗的患者。动脉压与血清环孢素A水平之间存在微弱的负相关关系。动脉压在第一个月最高,第三个月略有下降,随后又再次上升。动脉高血压的基本病因是排斥反应、原位保留的患者自身肾脏、移植肾动脉狭窄。

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