Takashima A, Matsunami E, Yamamoto K, Kitajima S, Mizuno N
Department of Dermatology, Nagoya City University Medical School, Japan.
Photodermatol Photoimmunol Photomed. 1990 Oct;7(5):218-21.
A total of 214 Japanese patients with psoriasis, under treatment with topical 8-methoxypsoralen and ultraviolet A (PUVA), were examined for malignant skin tumors and pigmented lesions during a follow-up period of up to 17 years (mean 5.8 years). One patient had developed multiple superficial basal cell carcinomas, and the remaining 213 patients had neither cutaneous carcinomas nor actinic keratoses. PUVA lentigines were seen in 89 patients (42%) and the incidence of lentigines increased as the number of PUVA treatments and the cumulative UVA dose increased. Melanocytic atypia was not observed histologically in 24 pigmented lesions examined. This report suggests that this topical PUVA regimen may not be highly carcinogenic in the Asian population.
共有214例接受外用8-甲氧基补骨脂素和紫外线A（PUVA）治疗的日本银屑病患者，在长达17年（平均5.8年）的随访期内接受了恶性皮肤肿瘤和色素沉着病变检查。1例患者发生了多发性浅表基底细胞癌，其余213例患者既无皮肤癌也无光化性角化病。89例患者（42%）出现了PUVA雀斑，且随着PUVA治疗次数和累积UVA剂量的增加，雀斑的发生率也增加。在检查的24个色素沉着病变中，组织学上未观察到黑素细胞异型性。本报告表明，这种外用PUVA方案在亚洲人群中可能不是高度致癌的。
