Burek C L, Bresler H S
Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.
Immunol Ser. 1990;52:169-90.
Genetics sets the groundwork for the predisposition to autoimmune thyroid disease, and in certain individuals, such as the juveniles presented here, very little impetus is needed to push normal immune reactions to autoimmune disease. However, in individuals who inherit only a few of these traits, the accumulation of many developmental and environmental insults may promote the development of disease.
遗传学为自身免疫性甲状腺疾病的易感性奠定了基础，对于某些个体，如本文所介绍的青少年，只需很少的诱因就能将正常免疫反应推向自身免疫性疾病。然而，对于仅继承了其中少数这些特征的个体，许多发育和环境损伤的累积可能会促进疾病的发展。
