Darling Downs Public Health Unit, Queensland Health, Queensland.
Aust N Z J Public Health. 2010 Feb;34(1):79-82. doi: 10.1111/j.1753-6405.2010.00478.x.
To describe the seroepidemiology of Coxiella burnetii, the causative agent of Q fever, in those under 25 years of age in South West Queensland.
A convenience sample of residual sera from a diagnostic laboratory was tested for C. burnetii antibodies by immunofluorescence at 1:10 dilution. Prevalence and annual incidence were calculated from the results.
Twenty-nine of 447 (6.5%, 95% CI 4.5%-9.2%) samples were positive. Seropositivity increased from 2.5% in those <15 (95% CI 1.0%-5.5%) to 11.0% in those 15-24 years old (95% CI 7.4%-16.0%). The estimated annual incidence for the latter age group was 7.7 per 1,000.
Q fever is a relatively common infection in South West Queensland, even in those aged <15 years for whom the vaccine is not recommended.
Vaccination programs, such as the federally funded National Q fever Management Program, are needed in this and similar high risk rural areas.
描述昆士兰州西南部 25 岁以下人群中，引起 Q 热的柯克斯体的血清流行病学情况。
采用免疫荧光法，对一家诊断实验室的剩余血清样本进行 Coxiella burnetii 抗体检测，检测稀释度为 1:10。根据检测结果计算患病率和年发病率。
447 份样本中，有 29 份（6.5%，95%置信区间：4.5%-9.2%）为阳性。血清阳性率从<15 岁人群的 2.5%（95%置信区间：1.0%-5.5%）上升到 15-24 岁人群的 11.0%（95%置信区间：7.4%-16.0%）。后者年龄组的估计年发病率为每 1000 人 7.7 例。
Q 热在昆士兰州西南部相当常见，即使对于不建议接种疫苗的<15 岁人群也是如此。
此类高风险农村地区需要开展疫苗接种项目，例如联邦政府资助的国家 Q 热管理计划。
