Meyer Morten, Jensen Pia, Rasmussen Jens Zimmer
Neurobiologisk Forskning, Institut for Molekylaer Medicin, Syddansk Universitet, Winsløwparken 21 st., 5000 Odense C, Denmark.
Ugeskr Laeger. 2010 Sep 20;172(38):2604-7.
Intrastriatal, foetal neural transplants can ameliorate symptoms in patients with Parkinson's and Huntington's disease, although not stop the primary cell-loss. Several issues must, however, be addressed before general or extended clinical use of cell therapy in neurodegenerative diseases can become a reality. Improvements include standardized and safe master cell-lines derived from human embryonic stem cells, induced pluripotent stem cells and neural stem cells. Cells from these sources are expected to become available for cell replacement therapies or therapeutic production of trophic, anti-inflammatory and restorative factors within a few years.
纹状体内胎儿神经移植可改善帕金森病和亨廷顿病患者的症状，尽管无法阻止原发性细胞损失。然而，在神经退行性疾病中细胞疗法能够普遍或广泛用于临床之前，必须解决几个问题。改进措施包括从人类胚胎干细胞、诱导多能干细胞和神经干细胞中获得标准化且安全的主细胞系。预计几年内可从这些来源获得细胞用于细胞替代疗法或用于营养、抗炎和恢复因子的治疗性生产。
