Baxevanis C N, Frillingos S, Seferiadis K, Reclos G J, Arsenis P, Katsiyiannis A, Anastasopoulos E, Tsolas O, Papamichail M
Department of Immunology, Hellenic Anticancer Institute, Athens, Greece.
Immunopharmacol Immunotoxicol. 1990;12(4):595-617. doi: 10.3109/08923979009019679.
The in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. ProT alpha by itself did not exert any IL-2 activity. Finally, ProT alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems.
将植物血凝素（PHA）或同种异体抗原刺激的外周血T细胞与胸腺素α原（ProTα）进行体外孵育，可导致白细胞介素-2（IL-2）的产生显著且可重复地增加。在不存在PHA或同种异体抗原的情况下，将T细胞与ProTα孵育不能诱导任何IL-2的产生。ProTα自身不发挥任何IL-2活性。最后，ProTα被证明可增加植物血凝素或同种异体抗原激活的T细胞上IL-2受体的表达。这些数据为理解ProTα在细胞免疫系统中的体外免疫增强作用提供了基础。
