氯化汞对白细胞迁移的抑制作用。

Mercuric chloride inhibition of leucocyte migration.

作者信息

Nordlind K, Lidén S

机构信息

Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.

出版信息

Immunopharmacol Immunotoxicol. 1990;12(4):715-21. doi: 10.3109/08923979009019686.

DOI:10.3109/08923979009019686

PMID:2092047

Abstract

The effects of mercuric chloride, at different concentrations, were tested on polymorphonuclear and mononuclear leucocyte migration by using the sealed capillary migration technique, and these effects were compared to influence on cell number and dye exclusion. A migration inhibition was obtained at 1.1 x 10(-5) M when tested on polymorphonuclear cells, while a concentration of 6.6 x 10(-5) inhibited the migration of mononuclear cells. Polymorphonuclear cells seemed to be more sensitive (were inhibited at a lower dose) to mercuric chloride as regards migration compared to cell number and dye exclusion, while mononuclear cells showed migration inhibition at about the same dose range as that which had effect on dye exclusion and cell number.

摘要

采用密封毛细管迁移技术，测试了不同浓度氯化汞对多形核白细胞和单核白细胞迁移的影响，并将这些影响与对细胞数量和染料排斥的影响进行了比较。在用多形核细胞进行测试时，浓度为1.1×10⁻⁵ M时出现迁移抑制，而浓度为6.6×10⁻⁵ M时抑制单核细胞的迁移。就迁移而言，与细胞数量和染料排斥相比，多形核细胞似乎对氯化汞更敏感（在较低剂量下受到抑制），而单核细胞在对染料排斥和细胞数量有影响的大致相同剂量范围内表现出迁移抑制。