Vermeersch Pieter, Richter Thomas, Hauer Almuthe C, Stern Martin, Uhlig Holm H, Zimmer Klaus-Peter, Laass Martin W, Hoffman Ilse, Hiele Martin, Mothes Thomas, Bossuyt Xavier
Laboratory Medicine, Immunology, University Hospitals Leuven, Catholic University of Leuven, Belgium.
Clin Biochem. 2011 Feb;44(2-3):248-50. doi: 10.1016/j.clinbiochem.2010.09.026. Epub 2010 Oct 12.
To evaluate whether taking into account anti-deamidated gliadin peptide (DGP) antibody concentrations improves clinical interpretation.
We calculated likelihood ratios (LR) using data from two previously published studies for assays from EUROIMMUN and INOVA.
LRs markedly increased with increasing IgG anti-DGP concentrations. LRs also increased with increasing IgA anti-DGP concentrations, although they were lower than for IgG anti-DGP.
Use of LRs for different test result intervals improves clinical interpretation.
评估考虑抗去酰胺化麦醇溶蛋白多肽（DGP）抗体浓度是否能改善临床解读。
我们使用之前发表的两项研究中来自EUROIMMUN和INOVA检测的数据计算似然比（LR）。
似然比随着抗DGP IgG浓度的增加而显著升高。似然比也随着抗DGP IgA浓度的增加而升高，尽管其低于抗DGP IgG的似然比。
针对不同检测结果区间使用似然比可改善临床解读。
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