Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi-110029, India.
J Pediatr Surg. 2010 Oct;45(10):2071-3. doi: 10.1016/j.jpedsurg.2010.07.028.
Ifosfamide used in the treatment of pediatric solid tumors is known to have serious adverse effects, including acute pancreatitis, a rare complication of therapy. This report describes a young girl who developed acute pancreatitis while being treated for recurrent Wilms tumor with the ifosfamide, carboplatin, and etoposide regimen. She recovered completely and without sequelae from ifosfamide-induced pancreatitis soon after the drug was stopped. Abdominal pain in patients on anticancer treatment is a common occurrence, but it is rarely investigated. Patients who receive ifosfamide as part of a chemotherapy regimen should be carefully monitored, and symptoms or signs suggestive of acute pancreatitis should be promptly investigated. Withholding the drug usually leads to complete recovery.
异环磷酰胺在治疗儿科实体瘤时已知有严重的不良反应，包括急性胰腺炎，这是一种罕见的治疗并发症。本报告描述了一名年轻女孩在接受异环磷酰胺、卡铂和依托泊苷方案治疗复发性肾母细胞瘤时发生急性胰腺炎。她在停药后很快从异环磷酰胺引起的胰腺炎中完全康复，没有后遗症。接受抗癌治疗的患者出现腹痛是很常见的，但很少进行调查。接受异环磷酰胺作为化疗方案一部分的患者应密切监测，并应及时调查有急性胰腺炎症状或体征的患者。停止使用该药物通常会导致完全康复。
