1,10-菲咯啉与氨基酸的某些混合配体铂（II）配合物的合成、表征及DNA结合研究

Synthesis, characterization, and DNA binding studies of some mixed-ligand platinum(II) complexes of 1,10-phenanthroline and amino acids.

作者信息

Mital R, Srivastava T S

机构信息

Department of Chemistry, Indian Institute of Technology, Bombay.

出版信息

J Inorg Biochem. 1990 Oct;40(2):111-20. doi: 10.1016/0162-0134(90)80044-x.

DOI:10.1016/0162-0134(90)80044-x

PMID:2092075

Abstract

A series of complexes of the type [Pt(phen)(AA)]+ (where AA is the anion of glycine, L-alanine, L-leucine, L-phenylalanine, L-tyrosine, or L-tryptophan) has been synthesized. These complexes have been characterized by electronic absorption, infrared, and 1H NMR spectroscopy. The interaction of these complexes with calf thymus DNA has been studied using fluorescence spectroscopy. They inhibit the intercalation of ethidium bromide in DNA by intercalative binding at low concentrations and show nonintercalative binding at higher concentrations.

摘要

已合成了一系列通式为[Pt(phen)(AA)]⁺的配合物（其中AA是甘氨酸、L-丙氨酸、L-亮氨酸、L-苯丙氨酸、L-酪氨酸或L-色氨酸的阴离子）。这些配合物已通过电子吸收光谱、红外光谱和¹H NMR光谱进行了表征。使用荧光光谱研究了这些配合物与小牛胸腺DNA的相互作用。它们在低浓度下通过插入结合抑制溴化乙锭在DNA中的插入，并在较高浓度下表现出非插入结合。