铑（II）和铑（III）与DNA的相互作用。

The interaction of Rh(II) and Rh(III) with DNA.

作者信息

Tselepi-Kalouli E, Katsaros N

机构信息

Institute of Physical Chemistry, National Research Center, Democritos, Athens, Greece.

出版信息

J Inorg Biochem. 1990 Oct;40(2):95-102. doi: 10.1016/0162-0134(90)80042-v.

DOI:10.1016/0162-0134(90)80042-v

PMID:2092079

Abstract

The interaction of Rh2(II)(acetate)4, cis-[Rh(III)(en)2Cl2] Cl (en = ethylenediamine) and [Rh(III) (NH3)5Cl]Cl2 with calf thymus DNA has been studied at various r values [formula; see text] and interaction times. Electronic spectra, melting and cooling curves and sedimentation data indicate no interaction of the acetate complex with DNA, except in the case of a high r value and long interaction time. The other two complexes have been found to interact with the phosphate groups, thus stabilizing the macromolecule.

摘要

已经在不同的r值[公式；见正文]和相互作用时间下研究了Rh2(II)(乙酸盐)4、顺式-[Rh(III)(乙二胺)2Cl2]Cl（乙二胺 = ethylenediamine）和[Rh(III)(NH3)5Cl]Cl2与小牛胸腺DNA的相互作用。电子光谱、熔解和冷却曲线以及沉降数据表明，除了在高r值和长相互作用时间的情况下，乙酸盐配合物与DNA没有相互作用。已发现另外两种配合物与磷酸基团相互作用，从而使大分子稳定。