Frearson Julie, Wyatt Paul
Drug Discovery Unit, College of Life Sciences, Dundee, UK.
Expert Opin Drug Discov. 2010 Oct 1;5(10):909-19. doi: 10.1517/17460441.2010.506508.
As the pharmaceutical industry continues to re-strategise and focus on low-risk, relatively short term gains for the sake of survival, we need to re-invigorate the early stages of drug discovery and rebalance efforts towards novel modes of action therapeutics and neglected genetic and tropical diseases. Academic drug discovery is one model which offers the promise of new approaches and an alternative organisational culture for drug discovery as it attempts to apply academic innovation and thought processes to the challenge of discovering drugs to address real unmet need.
随着制药行业为求生存而持续重新制定战略并专注于低风险、相对短期的收益,我们需要重振药物发现的早期阶段,并将努力重新平衡到新型作用模式的治疗方法以及被忽视的遗传和热带疾病上。学术性药物发现是一种模式,它有望带来新方法,并为药物发现提供一种不同的组织文化,因为它试图将学术创新和思维过程应用于发现药物以满足实际未满足需求的挑战中。