Sage Bionetworks, Seattle, Washington, USA.
Clin Pharmacol Ther. 2010 May;87(5):536-9. doi: 10.1038/clpt.2010.40.
If you doubt that there are enormous gaps in the current drug discovery process, you should probably skip to the next article. Yet even while critiques rightly highlight inefficiencies or operational issues, they often miss a fundamental reality: until we better understand diseases as altered bionetworks and view diseases at an individual patient level, efforts to develop effective biomarkers and therapies will be inefficient at best.
如果你怀疑当前的药物发现过程存在巨大的差距,你可能应该跳过下一篇文章。然而,即使批评者正确地强调了效率低下或运营问题,他们也常常忽略了一个基本事实:除非我们更好地理解疾病作为改变的生物网络,并在个体患者水平上看待疾病,否则开发有效的生物标志物和疗法的努力充其量也将是低效的。