氯化锂对 Zn 介导的不对称肉桂酰化反应立体控制的显著影响：β-芳基高烯丙基胺的高实用合成。
Dramatic lithium chloride effect on the reaction stereocontrol in Zn-mediated asymmetric cinnamylation: highly practical synthesis of β-aryl homoallylic amines.
机构信息
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
出版信息
Chem Commun (Camb). 2010 Nov 28;46(44):8460-2. doi: 10.1039/c0cc03230a. Epub 2010 Oct 4.
PMID:20922233
Abstract
An extremely mild and practical approach for the preparation of enantiomerically enriched β-aryl substituted homoallylic amines bearing two adjacent stereogenic centers was realized by room temperature zinc-mediated highly stereoselective cinnamylation of N-sulfinyl imines.
摘要
通过室温下锌介导的 N-亚磺酰亚胺的高对映选择性肉桂基化反应，实现了一种非常温和且实用的方法，用于制备具有两个相邻手性中心的对映体富集的β-芳基取代的偕丙基胺。
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