Service de Pneumologie, Unité d'Addictologie, CH Jacques Lacarin, Vichy, France.
Chest. 2010 Oct;138(4):989-91. doi: 10.1378/chest.10-0410.
Tobacco smoking is a well-recognized risk factor for Legionnaires disease. However, it may be potentiated by cannabis use, as there is strong evidence that Δ(9)-tetrahydrocannabinol impairs immune functions in vitro and in vivo. We report herein two out of three cases of severe Legionnaires disease in three men with no overt comorbid illnesses, aged 38, 28, and 48 years, respectively. All of them were heavy cigarette and cannabis smokers.
吸烟是军团病的一个公认的危险因素。然而，它可能会因大麻的使用而加剧，因为有强有力的证据表明Δ(9)-四氢大麻酚会损害体外和体内的免疫功能。我们在此报告三例严重军团病中的两例，这三例分别发生在三名没有明显合并症的男性患者中，年龄分别为 38 岁、28 岁和 48 岁。他们都是重度吸烟和吸食大麻者。
