阿根廷布宜诺斯艾利斯临床实践中与奈韦拉平相关的毒性反应
Nevirapine-associated toxicity in clinical practice in Buenos Aires, Argentina.
作者信息
Bottaro Edgardo Gabriel, Huberman Mara Judith, Iannella María Del Carmen, Vesperoni Fernando Adrián, Scapellato Pablo Gustavo, Errea Sylvia, Antonelli Leslie, Cassetti Lidia Isabel
机构信息
Helios Salud and Hospital General de Agudos Donación F. Santojanni, Buenos Aires, Argentina.
出版信息
J Int Assoc Physicians AIDS Care (Chic). 2010 Sep-Oct;9(5):306-12. doi: 10.1177/1545109710376250.
OBJECTIVES
to determine the incidence and risk factors for nevirapine (NVP)-associated toxicity in a cohort of HIV-infected people in Buenos Aires, Argentina.
DESIGN
retrospective study.
METHODS
HIV-infected adults who received NVP-based highly active antiretroviral therapy (HAART) at least for 2 weeks between May 1997 and March 2008 were included in this study. We analyzed patients' age, gender, HIV transmission route, HIV disease stage, pregnancy, alcohol intake, adverse events, coinfection with hepatitis B or C virus, time until toxicity, and withdrawal rates.
RESULTS
a total of 1110 patients (631 men) were included. Rash was the most frequently observed adverse event; it was more frequent in women. The incidence of severe rash and hepatotoxicity was similar in women and men. Female sex was the only variable significantly associated with mild-to-moderate rash. High CD4 count, pregnancy, and chronic hepatitis were not associated with NVP-related toxicity. An undetectable viral load at the time of starting NVP treatment resulted in a lower risk of NVP-related rash.
目的
确定阿根廷布宜诺斯艾利斯一组感染HIV人群中奈韦拉平（NVP）相关毒性的发生率及危险因素。
设计
回顾性研究。
方法
本研究纳入了1997年5月至2008年3月期间接受至少为期2周基于奈韦拉平的高效抗逆转录病毒治疗（HAART）的HIV感染成人。我们分析了患者的年龄、性别、HIV传播途径、HIV疾病分期、妊娠情况、酒精摄入、不良事件、乙型或丙型肝炎病毒合并感染情况、出现毒性反应的时间以及停药率。
结果
共纳入1110例患者（631例男性）。皮疹是最常观察到的不良事件；在女性中更常见。严重皮疹和肝毒性的发生率在女性和男性中相似。女性是与轻至中度皮疹显著相关的唯一变量。高CD4细胞计数、妊娠和慢性肝炎与NVP相关毒性无关。开始NVP治疗时病毒载量不可检测会降低NVP相关皮疹的风险。
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