乳腺癌患者接受外照射放疗前后血清硒水平。

Serum levels of selenium in patients with breast cancer before and after treatment of external beam radiotherapy.

机构信息

Department of Radiation Oncology, Clinica de Radioterapia Ingá (CRI), Brazilian Institute of Oncology (IBO), Niterói; Department of Radiation Oncology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro; Department of Radiology, Clementino Fraga Filho University Hospital of Rio de Janeiro Federal University, Rio de Janeiro; Department of Nutrition, Josué de Castro Institute of Nutrition (INJC), Center of Research for Micronutrients (NPqM), Rio de Janeiro Federal University, Rio de Janeiro, Brazil.

Department of Nutrition, Josué de Castro Institute of Nutrition (INJC), Center of Research for Micronutrients (NPqM), Rio de Janeiro Federal University, Rio de Janeiro, Brazil.

出版信息

Ann Oncol. 2011 May;22(5):1109-1112. doi: 10.1093/annonc/mdq547. Epub 2010 Oct 5.

DOI:10.1093/annonc/mdq547

PMID:20924074

Abstract

BACKGROUND

To evaluate the influence of radiotherapy on the selenium serum levels of breast cancer patients.

PATIENTS AND METHODS

This prospective study includes 209 breast cancer patients treated by external beam radiotherapy from December 2007 until August 2008. Plasma selenium concentrations were determined before and at the end of the radiotherapeutic treatment. Age, clinical stage, prior chemotherapy, body mass index (BMI) and personal habits (smoking and alcoholism) were recorded for each patient.

RESULTS

The mean age was 61 years; the mean BMI was 28.7. One hundred and seventy-four patients (83.3%) were nonsmokers. One hundred and eighty-nine patients (90.4%) showed no drinking habits and 110 (52.6%) have no prior chemotherapy. Sixty patients (28.7%) were in clinical stage I, 141 (67.5%) in clinical stage II and 8 (3.8%) in clinical stage III. At the beginning of radiotherapy, the mean selenium value for all patients was 86.4 μg/l and after radiation this value dropped to 47.8 μg/l. Multivariate analysis showed statistically significant difference in the plasma selenium concentration before and after radiotherapy for age (P > 0.001), BMI (P > 0.001), smoking (P > 0.001), alcoholism (P > 0.001), chemotherapy (P > 0.001) and clinical stage (P > 0.001).

CONCLUSIONS

Significant reduction in plasma levels of selenium is recorded in patients undergoing radiotherapy, suggesting attention to the nutritional status of this micronutrient and other antioxidant agents.

摘要

背景

评估放疗对乳腺癌患者硒血清水平的影响。

患者和方法

本前瞻性研究纳入了 209 例于 2007 年 12 月至 2008 年 8 月接受外照射放疗的乳腺癌患者。在放疗前和放疗结束时测定血浆硒浓度。记录每位患者的年龄、临床分期、既往化疗、体重指数（BMI）和个人习惯（吸烟和酗酒）。

结果

平均年龄为 61 岁；平均 BMI 为 28.7。174 例（83.3%）患者为非吸烟者。189 例（90.4%）无饮酒习惯，110 例（52.6%）无既往化疗。60 例（28.7%）为临床 I 期，141 例（67.5%）为临床 II 期，8 例（3.8%）为临床 III 期。放疗开始时，所有患者的平均硒值为 86.4μg/l，放疗后降至 47.8μg/l。多变量分析显示，放疗前后血浆硒浓度在年龄（P > 0.001）、BMI（P > 0.001）、吸烟（P > 0.001）、酗酒（P > 0.001）、化疗（P > 0.001）和临床分期（P > 0.001）方面有统计学显著差异。