Biosyn Arzneimittel GmbH, Schorndorfer Straße 32, 70734 Fellbach, Germany.
Lympho Opt Fachklinik, Happurger Straße 15, 91224 Hohenstadt, Germany.
Nutrients. 2020 Apr 25;12(5):1211. doi: 10.3390/nu12051211.
Selenium is a trace element, which is utilized by the human body in selenoproteins. Their main function is to reduce oxidative stress, which plays an important role in lymphedema and lipedema. In addition, selenium deficiency is associated with an impaired immune function. The aim of this study was to determine the prevalence of selenium deficiency in these conditions, and if it is associated with disease severity and an associated medical condition such as obesity.
This cross-sectional study is an anonymized, retrospective analysis of clinical data that was routinely recorded in a clinic specialized in lymphology. The data was comprised from 791 patients during 2012-2019, in which the selenium status was determined as part of their treatment.
Selenium deficiency proved common in patients with lymphedema, lipedema, and lipo-lymphedema affecting 47.5% of the study population. Selenium levels were significantly lower in patients with obesity-related lymphedema compared to patients with cancer-related lymphedema (96.6 ± 18.0 μg/L vs. 105.1 ± 20.2 μg/L; < 0.0001). Obesity was a risk factor for selenium deficiency in lymphedema (OR 2.19; 95% CI 1.49 to 3.21), but not in lipedema.
In countries with low selenium supply, selenium deficiency is common, especially in lymphedema patients. Therefore, it would be sensible to check the selenium status in lymphedema patients, especially those with obesity, as the infection risk of lymphedema is already increased.
硒是一种微量元素，人体利用硒蛋白来获取硒。它们的主要功能是减少氧化应激，氧化应激在淋巴水肿和脂肪水肿中起着重要作用。此外，硒缺乏与免疫功能受损有关。本研究旨在确定这些疾病中硒缺乏的流行情况，以及它是否与疾病严重程度和肥胖等相关疾病有关。
这是一项横断面研究，对专门从事淋巴学的诊所中常规记录的临床数据进行匿名、回顾性分析。该数据来自 2012 年至 2019 年期间的 791 名患者，在治疗过程中确定了他们的硒状况。
研究表明，患有淋巴水肿、脂肪水肿和脂肪-淋巴水肿的患者中硒缺乏较为常见，占研究人群的 47.5%。与癌症相关的淋巴水肿患者相比，肥胖相关的淋巴水肿患者的硒水平明显较低（96.6 ± 18.0 μg/L 比 105.1 ± 20.2 μg/L；<0.0001）。肥胖是淋巴水肿患者硒缺乏的危险因素（OR 2.19；95%CI 1.49 至 3.21），但不是脂肪水肿。
在硒供应不足的国家，硒缺乏很常见，尤其是在淋巴水肿患者中。因此，检查淋巴水肿患者，尤其是肥胖患者的硒状况是明智的，因为淋巴水肿的感染风险已经增加。
