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trabectidin 在促结缔组织增生性小圆细胞肿瘤中的活性。

Activity of trabectidin in desmoplastic small round cell tumor.

机构信息

Medical Oncology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

出版信息

Med Oncol. 2011 Dec;28 Suppl 1:S644-6. doi: 10.1007/s12032-010-9687-9. Epub 2010 Oct 7.

DOI:10.1007/s12032-010-9687-9
PMID:20924717
Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive cancer that typically arises in teenage boys. As a result of its low prevalence, there have been few studies of its treatment and impact on survival. Here, we report the case of a patient who was refractory to multiple drugs but remains stable with trabectedin. To our knowledge, this is the first published report that supports antitumoral activity of trabectedin in DSRCT.

摘要

促纤维增生性小圆细胞肿瘤(DSRCT)是一种罕见且侵袭性强的癌症,通常发生在青少年男性中。由于其发病率低,对其治疗和生存影响的研究很少。在这里,我们报告了一例对多种药物耐药但仍用曲贝替定稳定的患者。据我们所知,这是第一份支持曲贝替定在 DSRCT 中具有抗肿瘤活性的发表报告。

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Activity of trabectidin in desmoplastic small round cell tumor. trabectidin 在促结缔组织增生性小圆细胞肿瘤中的活性。
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2
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引用本文的文献

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Effectiveness of irinotecan plus trabectedin on a desmoplastic small round cell tumor patient-derived xenograft.irinotecan 联合 trabectedin 治疗 desmoplastic small round cell tumor 患者来源异种移植瘤的疗效。
Dis Model Mech. 2023 Jun 1;16(6). doi: 10.1242/dmm.049649. Epub 2023 Jun 14.
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Intra-Abdominal Desmoplastic Small Round Cell Tumor: Current Treatment Options and Perspectives.腹腔内促结缔组织增生性小圆细胞肿瘤:当前的治疗选择与展望
Front Oncol. 2021 Sep 15;11:705760. doi: 10.3389/fonc.2021.705760. eCollection 2021.
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Desmoplastic small round cell tumors: Multimodality treatment and new risk factors.

本文引用的文献

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Trabectedin in myxoid liposarcomas (MLS): a long-term analysis of a single-institution series.曲贝替定治疗黏液样脂肪肉瘤(MLS):单机构系列的长期分析
Ann Oncol. 2009 Aug;20(8):1439-44. doi: 10.1093/annonc/mdp004. Epub 2009 May 22.
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Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors.曲贝替定(ET - 743)可促进黏液样脂肪肉瘤肿瘤的分化。
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Role of homologous recombination in trabectedin-induced DNA damage.同源重组在曲贝替定诱导的DNA损伤中的作用。
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Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival.多模态治疗促纤维增生性小圆细胞肿瘤:化疗和完全细胞减灭术可改善患者生存。
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Antiangiogenic effects in patients with progressive desmoplastic small round cell tumor: data from the French national registry dedicated to the use of off-labeled targeted therapy in sarcoma (OUTC's).进展性促结缔组织增生性小圆细胞肿瘤患者的抗血管生成作用:来自法国国家肉瘤超适应证靶向治疗登记处(OUTC's)的数据。
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Mechanism of action of trabectedin in desmoplastic small round cell tumor cells. trabectedin 在促结缔组织增生性小圆细胞肿瘤细胞中的作用机制。
BMC Cancer. 2017 Feb 6;17(1):107. doi: 10.1186/s12885-017-3091-1.
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Complete response after rechallenge with trabectedin in a patient with previously responding high-grade undifferentiated sarcoma.
Anticancer Drugs. 2016 Oct;27(9):908-13. doi: 10.1097/CAD.0000000000000398.
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Pazopanib in advanced desmoplastic small round cell tumours: a multi-institutional experience.帕唑帕尼治疗晚期促纤维组织增生性小圆细胞肿瘤:一项多机构经验
Clin Sarcoma Res. 2014 Jul 29;4:7. doi: 10.1186/2045-3329-4-7. eCollection 2014.
10
Trabectedin for desmoplastic small round cell tumours: a possible treatment option?曲贝替定用于促纤维组织增生性小圆细胞肿瘤:一种可能的治疗选择?
Clin Sarcoma Res. 2014 Apr 25;4:3. doi: 10.1186/2045-3329-4-3. eCollection 2014.
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Desmoplastic small round cell tumour: a review of literature and treatment options.促纤维增生性小圆细胞瘤:文献综述及治疗选择
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Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NER-proficient cells, unravelled by a novel mathematical simulation approach.通过一种新颖的数学模拟方法揭示曲贝替定(ET-743)在核苷酸切除修复(NER)缺陷和NER正常细胞中对细胞周期阶段扰动的动力学。
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Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.复制和同源重组修复调节抗肿瘤烷化剂埃博霉素743诱导的DNA双链断裂形成。
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Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study.曲贝替定(ET-743)治疗晚期经治黏液样脂肪肉瘤的疗效:一项回顾性研究。
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Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin.抗肿瘤药物曲贝替定作用机制中核苷酸切除修复与同源重组DNA修复途径之间的相互作用
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Intraabdominal desmoplastic small round cell tumors: a diagnostic and therapeutic challenge.腹腔促结缔组织增生性小圆细胞肿瘤:诊断与治疗的挑战
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