Department of Ophthalmology, Union Hospital , Hong Kong.
J Ocul Pharmacol Ther. 2010 Oct;26(5):519-21. doi: 10.1089/jop.2010.0069.
To report a case of Pseudallescheria boydii keratitis successfully treated with topical natamycin as monotherapy.
Interventional case report describing the clinical presentation, histopathologic findings, course, and treatment of a patient with P. boydii keratitis.
A 50-year-old male electrician with a 4-day history of right eye pain and blurring of vision was referred. There was history of right eye injury while hammering and examining a hole in the ceiling. Examination showed a corneal abscess with overlying epithelial defect measuring 2 mm in diameter. Histopathologic investigation revealed septate hyaline cylindrical hyphae with acute angle branching and formation of oval to pyriform conidia truncated at the base, compatible with P. boydii. The patient was treated with topical natamycin 5%, which eradicated the infection, resulting in a final best-corrected visual acuity of 6/7.5.
The fungus P. boydii can cause keratitis. The success rate for treatment was generally thought to be poor. Early detection and treatment is important in improving the outcome. This is believed to be the first reported case of P. boydii keratitis successfully treated with topical natamycin as monotherapy.
报告一例假丝酵母菌角膜炎，经局部那他霉素单药治疗成功。
描述了一名假丝酵母菌角膜炎患者的临床表现、组织病理学发现、病程和治疗的介入性病例报告。
一名 50 岁男性电工，右眼疼痛和视力模糊 4 天，前来就诊。他在天花板上敲洞时右眼受伤。检查发现直径 2 毫米的角膜脓肿，伴有上皮缺损。组织病理学检查显示有分隔的透明圆柱形菌丝，锐角分枝，形成椭圆形至梨形分生孢子，在基部截断，与假丝酵母菌相符。患者接受局部那他霉素 5%治疗，消除了感染，最终最佳矫正视力为 6/7.5。
假丝酵母菌可引起角膜炎。一般认为其治疗成功率较低。早期发现和治疗对改善预后很重要。这被认为是首例假丝酵母菌角膜炎经局部那他霉素单药治疗成功的报告。
