Briant T D, Fitzpatrick P J, Berman J
Laryngoscope. 1978 Aug;88(8 Pt 1):1247-51. doi: 10.1288/00005537-197808000-00005.
A control rate of approximately 80% has been obtained in 45 cases of juvenile nasopharyngeal angiofibroma treated by a single moderate dose of radiotherapy at the Princess Margaret Hospital, Toronto. The remaining patients ultimately achieved control generally after further irradiation. Immediate side-effects of the treatment have been minimal, and no late complications have been observed. In 2-20 years' follow-up, no irradiation-induced tumors have been found. Superiority of irradiation in these cases over surgery is emphasized, as well as the importance of using sophisticated techniques to limit the volume of tissues irradiated and protect vulnerable radiosenstitive structures. Because tumor regression can be expected to continue for many months after treatment has been completed, a policy of observation following radiotherapy is recommended.
在多伦多玛格丽特公主医院，45例青少年鼻咽血管纤维瘤患者接受单次中等剂量放疗后，控制率约为80%。其余患者通常在进一步放疗后最终实现病情控制。治疗的即时副作用极小，且未观察到晚期并发症。在2至20年的随访中，未发现放疗诱发的肿瘤。强调了放疗在这些病例中相对于手术的优势，以及使用先进技术限制受照射组织体积和保护易受辐射影响的敏感结构的重要性。由于预计肿瘤消退在治疗完成后会持续数月，因此建议采取放疗后观察的策略。
