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非洲分枝杆菌——西非人类结核病的一个重要病因综述。

Mycobacterium africanum--review of an important cause of human tuberculosis in West Africa.

机构信息

MRC Laboratories, Bacterial Diseases Programme, Fajara, The Gambia.

出版信息

PLoS Negl Trop Dis. 2010 Sep 28;4(9):e744. doi: 10.1371/journal.pntd.0000744.

DOI:10.1371/journal.pntd.0000744
PMID:20927191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2946903/
Abstract

Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. In this review we discuss the definition of M. africanum, describe the prevalence and restricted geographical distribution of M. africanum West African 1 and 2, review the occurrence of M. africanum in animals, and summarize the phenotypic differences described thus far between M. africanum and M. tuberculosis sensu stricto.

摘要

非洲分枝杆菌属于结核分枝杆菌复合群中两个具有明显系统发育差异的分枝杆菌种,分别称为西非 1 型和西非 2 型非洲分枝杆菌。这两种分枝杆菌局限于西非,在那里它们导致多达一半的人类肺结核。在这篇综述中,我们讨论了非洲分枝杆菌的定义,描述了西非 1 型和 2 型非洲分枝杆菌的流行情况和有限的地理分布,回顾了在动物中出现的非洲分枝杆菌,总结了迄今为止非洲分枝杆菌与结核分枝杆菌狭义概念之间描述的表型差异。

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