Zagari A, Némethy G, Scheraga H A
Dipartimento di Chimica, Università di Napoli, Italy.
Biopolymers. 1990;30(9-10):961-6. doi: 10.1002/bip.360300910.
The alteration of polymer conformational properties caused by the replacement of L-proline by L-azetidine-2-carboxylic acid (Aze) has been studied by means of conformational energy computations. In addition to poly(Aze), two sequential copolymers, poly(Pro-Aze) and poly(Aze3-Pro3), have been investigated. All polymers containing Aze are more flexible than poly(Pro). This is a consequence of an increased number of permitted conformational states for the Aze residue, as compared to Pro, when they are incorporated into a polypeptide, as well as of a lessened cooperativity of the trans-cis transition. The results of the computation can be used to interpret the observed physical properties of poly(Aze) and of its copolymers.
通过构象能量计算研究了用L-氮杂环丁烷-2-羧酸（Aze）取代L-脯氨酸所引起的聚合物构象性质的改变。除了聚（Aze）之外，还研究了两种顺序共聚物，聚（Pro-Aze）和聚（Aze3-Pro3）。所有含Aze的聚合物都比聚（Pro）更具柔性。这是由于当Aze残基被并入多肽中时，与Pro相比，其允许的构象状态数量增加，以及反式-顺式转变的协同性降低。计算结果可用于解释聚（Aze）及其共聚物所观察到的物理性质。
