Itsekson Alek, Shepshelovich Daniel, Kanevsky Alex, Seidman Daniel S
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Isr Med Assoc J. 2010 Jun;12(6):334-7.
Non-invasive screening tests may allow early diagnosis and prompt treatment, thereby potentially reducing morbidity and mortality and reducing costs for the community. This may be especially important for gynecologic pathologies that are difficult to promptly diagnose, such as endometriosis or ovarian cancer.
To evaluate the reliability of measuring skin resistance using the Medex Test for screening and diagnosis of gynecologic pathologies in a blinded single-center study.
We enrolled 150 patients: 59 with a functional disorder and 91 with an organic disease. Measurements were carried out in all patients and the results were analyzed separately by a second physician who was blinded to the patients' diagnosis.
A high correlation was found between the clinical diagnosis and the results of the measurement of electrical skin resistance, with a specificity of 76.3% (45/59) for functional disorders and a sensitivity of 85.7% (78/91) for organic disorders, positive predictive value of 84.8% (78/92) and negative predictive value 77.6% (45/58). The kappa value for the results was 0.622, representing a value much better than expected randomly.
The Medex Test has a good specificity and a high sensitivity for the diagnosis of gynecologic disorders. Further prospective studies are needed to validate these preliminary findings.
非侵入性筛查测试可实现早期诊断和及时治疗，从而有可能降低发病率和死亡率，并降低社区成本。这对于难以迅速诊断的妇科疾病（如子宫内膜异位症或卵巢癌）可能尤为重要。
在一项单中心双盲研究中，评估使用Medex测试测量皮肤电阻以筛查和诊断妇科疾病的可靠性。
我们招募了150名患者：59名患有功能性疾病，91名患有器质性疾病。对所有患者进行测量，并由另一位对患者诊断不知情的医生分别分析结果。
临床诊断与皮肤电阻测量结果之间存在高度相关性，功能性疾病的特异性为76.3%（45/59），器质性疾病的敏感性为85.7%（78/91），阳性预测值为84.8%（78/92），阴性预测值为77.6%（45/58）。结果的kappa值为0.622，表明该值比随机预期值好得多。
Medex测试对妇科疾病的诊断具有良好的特异性和高敏感性。需要进一步的前瞻性研究来验证这些初步发现。
