Yang Qing-you, Lu Shu, Sun Hui-ru
Wuxi Provincial Hospital of Traditional Chinese Medicine, Jiangsu.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Jul;30(7):699-701.
To explore the effects of Astragalus on cardiac function and serum tumor necrosis factor-alpha (TNF-alpha) level in patients with chronic heart failure (CHF).
Forty-five patients of Xin-qi deficiency or Xin-yang deficiency types were assigned to the Chinese medicine (CM) group and the Western medicine (WM) group by a randomizing digital table. Standard treatment for correcting heart failure, including digoxin, diuretics, etc. was administered to both groups, but to the CM group oral medication of Astragalus granule was given additionally at the dosage of 2.25 g twice a day, the treatment for both was continued for two weeks. NYHA cardiac functional grading, serum TNF-alpha level, left ventricular ejection fraction (LVEF) and walk distance in 6 min (WD) were measured before and after treatment, and a correlation analysis was carried out.
After therapy, the level of TNF-alpha in the two groups decreased (P < 0.05) and it was lower in the CM group [(54.77 +/- 9.34) microg/L] than in the WM group [(62.10 +/- 9.94) microg/L] (P < 0.05); LVEF in the two groups increased (P < 0.05) and it was higher in the CM group [(64.45 +/- 12.47)%] than that in the WM group [(56.03 +/- 13.33)%] (P < 0.05); both groups' WD increased (P < 0.05) and it was longer in the CM group [(446.97 +/- 68.82) m] than in the WM group [(345.40 +/- 63.62) m] (P < 0.05); the improvement of cardiac functional grading in the CM group was outstriper than the WM group (P < 0.05). The improvement in cardiac function was negatively correlated with TNF-alpha level.
Astragalus can alleviate the calcium overload-induced myocardial damage and improve both systolic and diastolic functions of heart in patients with CHF.
探讨黄芪对慢性心力衰竭（CHF）患者心功能及血清肿瘤坏死因子-α（TNF-α）水平的影响。
将45例心气虚或心阳虚型患者采用随机数字表法分为中药组和西药组。两组均给予纠正心力衰竭的标准治疗，包括地高辛、利尿剂等，中药组在此基础上额外给予黄芪颗粒口服，剂量为2.25 g，每日2次，两组均持续治疗2周。治疗前后测定纽约心脏协会（NYHA）心功能分级、血清TNF-α水平、左心室射血分数（LVEF）及6分钟步行距离（WD），并进行相关性分析。
治疗后，两组TNF-α水平均降低（P<0.05），且中药组[（54.77±9.34）μg/L]低于西药组[（62.10±9.94）μg/L]（P<0.05）；两组LVEF均升高（P<0.05），且中药组[（64.45±12.47）%]高于西药组[（56.03±13.33）%]（P<0.05）；两组WD均增加（P<0.05），且中药组[（446.97±68.82）m]长于西药组[（345.40±63.62）m]（P<0.05）；中药组心功能分级改善优于西药组（P<0.05）。心功能改善与TNF-α水平呈负相关。
黄芪可减轻钙超载所致的心肌损伤，改善CHF患者心脏的收缩和舒张功能。
