Chen Zhiye, Ma Lin
Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.
Amyotroph Lateral Scler. 2010 Dec;11(6):549-54. doi: 10.3109/17482968.2010.516265. Epub 2010 Oct 7.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with selected both upper and lower motor neuron involvement. Although some inconsistent results exist, both pathological studies and many structural neuroimaging studies have revealed brain volume changes in ALS. To provide an objective overview of structural changes in ALS, a voxel-wise meta-analysis was performed in published voxel based morphometry (VBM) studies. A systematic search of VBM studies was applied in ALS. Five studies met the inclusion criteria, comprising 84 ALS patients and 81 normal controls. A voxel-wise meta-analysis was performed on the retrieved VBM studies using signed differential mapping. Descriptive analysis showed that 25% of ALS patients had right precentral gyrus atrophy (2373 voxels). Group analysis demonstrated regional grey matter loss over the whole brain in the right precentral gyrus (p = 7.96 × 10(-4)). Sensitivity analysis showed good sensitivity (157 voxels). In conclusion, right precentral grey matter atrophy was a common finding and prominent feature of brain structural changes in ALS.
肌萎缩侧索硬化症（ALS）是一种进行性神经退行性疾病，其特征为上下运动神经元均有受累。尽管存在一些不一致的结果，但病理研究和许多结构性神经影像学研究均已揭示ALS患者存在脑容量变化。为了客观概述ALS患者的结构变化，我们对已发表的基于体素的形态学测量（VBM）研究进行了体素级荟萃分析。我们对ALS患者的VBM研究进行了系统检索。五项研究符合纳入标准，共纳入84例ALS患者和81例正常对照。我们使用符号差异映射对检索到的VBM研究进行了体素级荟萃分析。描述性分析显示，25%的ALS患者存在右侧中央前回萎缩（2373个体素）。组间分析表明，右侧中央前回存在全脑范围的灰质丢失（p = 7.96 × 10(-4)）。敏感性分析显示敏感性良好（157个体素）。总之，右侧中央前回灰质萎缩是ALS患者脑结构变化的常见且突出的特征。
